Purpuric-petechial eruption and aplastic crisis associated with human parvovirus B19 infection in a 9-year-old boy with hereditary spherocytosis: a case report

Abstract

Human parvovirus B19 (PVB19) is linked to several clinical manifestations, such as erythema infectiosum, aplastic crisis in patients suffering from chronic hemolytic anemia, and nonimmune hydrops fetalis. Recently, other unusual petechial or purpuric skin eruptions have been noted in association with PVB19 infection. Here, we report a rare case of aplastic crisis with petechial eruption, mainly on the trunk, in a 9-year-old boy with hereditary spherocytosis. In addition, a rash indicating erythema infectiosum developed during the sixth week of the disease. Purpuric-petechial eruption may be a good predictor of aplastic crisis in patients with chronic hemolytic disease.