2021 Volume 58 Issue 1 Pages 55-59
Trisomy 18 (T18) is a chromosomal disorder with poor prognosis, and more than 90% of T18 patients have congenital heart disease (CHD). Some patients develop malignant tumors such as hepatoblastoma (HB) and Wilms tumor. Recently, the application of radical or palliative surgery for CHD has improved patient prognosis, and an increasing number of patients have received home healthcare. Here, we describe the cases of two T18 patients diagnosed in the fetal period who developed HB during the clinical course. Both patients progressed to home healthcare without selecting surgical treatment for CHD. In addition, nontreatment supportive care was selected for HB. The natural clinical course of HB with T18 is unclear, but both patients survived for more than 2 years after diagnosis. There are few reports on the natural clinical course of HB associated with T18, and thus we believe that this report may provide information that can be used as a reference for future treatment policy selection.
