2021 Volume 58 Issue 3 Pages 311-314
Intensive multimodality therapy has led to a marked improvement in the clinical outcome of patients with nongerminomatous germ cell tumor (NGGCT). However, there have only been a limited number of studies on therapy-related secondary tumors. A 14-year-old woman was diagnosed as having high-risk intracranial NGGCT, and she received a combination of chemotherapy and radiotherapy (craniospinal irradiation of 22.4 Gy in 14 fractions and boost irradiation of 27.2 Gy to the primary tumor in 17 fractions), leading to long-term disease-free survival. At the age of 25, a pelvic MRI scan revealed an enhanced mass in the spinal cord of the fifth lumber vertebra. She underwent total resection of the tumor and was histopathologically diagnosed as having schwannoma. A shorter latency period was found between the treatment for the primary tumor and the onset of secondary schwannoma in this case than in previously reported cases (10.3 vs. 24.6 years). Intense treatment with a combination of chemotherapy and radiotherapy or genetic predisposition might be associated with early-onset schwannoma.
