Abstract
Research on late neurocognitive sequelae in long-term survivors of childhood cancer remains limited in Japan due to the lack of neurocognitive assessment tools. The objective of this study was to cross-culturally adapt and validate the Childhood Cancer Survivor Study Neurocognitive Questionnaire (CCSS-NCQ) to fill the research gap. The CCSS-NCQ, which is a standardized self-reported measure of neurocognitive function, is comprised of four domains: Task Efficiency, Emotional Regulation, Organization, and Memory. The Japanese translated version of CCSS-NCQ was distributed to 34 childhood cancer survivors, and its construct validity was evaluated by confirmatory factor analysis. A four-factor model identified in the original CCSS-NCQ was not confirmed. As opposed to the four-factor model identified in the original CCSS-NCQ, the three-factor model in which Memory and Efficiency converged to one factor, was observed. Since the majority of participants were brain tumor survivors, the results from this study may provide insights on the vulnerability of this group to treatment-related neurocognitive impairment. Further studies with a larger sample size are warranted to firmly evaluate the construct validity of the Japanese CCSS-NCQ.
