2022 Volume 59 Issue 1 Pages 44-49
Infantile fibrosarcoma (IF) is a rare soft tissue tumor of intermediate (rarely metastasizing) malignancy that occurs in infants. Treatment modalities should be chosen to avoid late-stage morbidities due to extensive resection and chemotherapy. We, herein, present the case of a three-month-old girl with IF extensively involving her left lower leg. She was administered a combination chemotherapy consisting of vincristine and actinomycin-D, and she showed marked shrinkage of the tumor. However, she experienced severe liver dysfunction and disseminated intravascular coagulation syndrome during the third course of chemotherapy; thus, the subsequent courses of chemotherapy were discontinued. The tumor continued to decrease in size. For more than 5 years, she was alive and well with only small foci of radiologic abnormality around the left ankle on MR images. Regarding treatment selection for IF, it is desirable to further establish case accumulation in the future.
