Abstract
Complete tumor resection is a critical prognostic factor in pediatric hepatic malignancies. In this study, we administered indocyanine green (ICG) preoperatively in two cases of pediatric hepatic malignant tumors to facilitate intraoperative navigation surgery. We observed the fluorescence histological images using a confocal microscope. Case 1, a seven-year-old girl diagnosed with undifferentiated embryonal sarcoma of the liver (UESL), underwent an extended right lobectomy. ICG did not accumulate in the tumor; however, it showed significant accumulation in the adjacent normal liver tissue. Case 2, a two-year-old girl diagnosed with hepatoblastoma (HB), underwent a right hepatic lobectomy. The patient exhibited strong accumulation of ICG in the tumor tissue, while no ICG accumulation was observed in the surrounding normal liver tissue. Confocal microscopy further elucidated distinct patterns of ICG accumulation between UESL and HB. Despite the variability in ICG accumulation patterns observed in each tumor type, ICG navigation surgery for these tumors was extremely effective in achieving complete tumor resection.
