A one-month-old boy with Kasabach–Merritt phenomenon who responded to sirolimus and prednisolone

Abstract

The Kasabach–Merritt phenomenon (KMP) is a condition characterized by increasing hemangioma accompanied by thrombocytopenia and coagulopathy, which can lead to death due to bleeding tendencies. Herein, we report the case of a one-month-old boy with KMP who had a favorable course after receiving sirolimus and prednisolone (PSL).

The patient was born with a hemangioma on the trunk, and at one month of age, the hemangioma began to enlarge, accompanied by subcutaneous hemorrhage. He was admitted to our hospital due to thrombocytopenia and coagulopathy.

KMP was confirmed, and the patient received PSL treatment along with supportive therapy. From the fourth day of hospitalization, sirolimus was added to the treatment regimen, and by the ninth day, the platelet count had increased, coagulopathy had improved, and the hemangioma showed a tendency to shrink. The condition remained stable thereafter.