2020 Volume 11 Issue 6 Pages 878-882
The intervertebral disc is one of the major contributors to low back pain. Most low back pain is usually self-limiting, but it is sometimes prolonged which is major problem in clinical situations. Possible mechanisms of chronic discogenic low back pain are a prolonged low back pain state and repeated injured state. "Deep Nerve Ingrowth" into an injured intervertebral disc, pain-related molecules including inflammatory cytokines and nerve growth factors and continuous mechanical stress on injured intervertebral discs might be associated with the mechanism of chronic discogenic low back pain.
