2025 Volume 42 Issue 3 Pages 218-223
A male in his 40s underwent surgery and adjuvant chemotherapy （XELOX） for rectal cancer. After completing chemotherapy, a solitary hepatic lesion appeared, raising suspicion of liver metastasis from rectal cancer, and partial hepatectomy was performed. Histopathologically, marked sinusoidal dilatation and congestion were observed. The sinusoidal endothelial cells were indistinct, and CD34-positive neovascularization was present. Hepatocytes showed no atypia. Consequently, the lesion was diagnosed as localized peliosis hepatis. Sinusoidal injury has been reported as a side effect of oxaliplatin-based chemotherapy. However, as in this case, when the lesion is localized, distinguishing it clinically from tumor metastasis can be challenging.
