Radiation-induced cerebellar glioblastoma occurring 36 years after therapy for germinoma

Abstract

We report the case of a patient in whom a radiation-induced cerebellar glioblastoma occurred 36 years after radiation therapy for germinoma. The patient had received cobalt irradiation (whole brain, 50 Gy) for germinoma treatment when he was 14 years old. Magnetic resonance imaging revealed a tumor in the left cerebellar hemisphere when the patient turned 50 years old, and this tumor was removed. The histopathological diagnosis of the tumor confirmed that it was a glioblastoma NOS. He received chemoradiotherapy with temozolomide and CyberKnife. It is necessary to perform a long-term follow-up after radiation therapy, and patients should be informed about the adverse effects of radiation therapy.