Abstract
Continuing with our ongoing project of chemical transformations of sesquiterpene lactones(SL) searching for new herbicide models, here in we present the results of an structure-activity relationship(SAR) with guaianolides.Chemical transformations have been introduced in the molecule aiming to analyse two main factors:a) In order to test the influence of an increasing lipophylicity in the activity we have get access to isozaluzanin C derivatives with linear or branched ester side chains of different lengths at the C-3 hydroxyl group.b) The second objective is to test the importance of chemical transformations into the lactone ring nearby positions.Consequently, changes in the double bond of the lactone ring were introduced in the course of a synthetic design to get access to an oxetane group attached to these positions preparing masked Michael acceptors.Compounds were tested using the wheat coleoptiles and the germination and growth Petri dish bioassays, and the results statistically analysed by cluster analysis.
