Plant and Cell Physiology Supplement
Supplement to Plant and Cell Physiology Vol. 46
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A bZIP transcription factor of Arabidopsis regulating the endoplasmic reticulum stress response in a manner specific to plants
*Yuji IwataNozomu Koizumi
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Pages 512

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Abstract
Proteins synthesized in the endoplasmic reticulum (ER) are correctly folded before translocation. If protein folding is incorrect, genes for the ER-resident chaperones such as BiP are induced. This phenomenon is known as the ER stress response. Studying molecular mechanism of the ER stress response in Arabidopsis, we identified a bZIP transcription factor AtbZIP60 induced by tunicamycin treatment. AtbZIP60 has a putative transmembrane domain in its C-terminal region. A truncated form without C-terminal region (AtbZIP60ΔC) fused with GFP localized to the nucleus. In addition, overexpression of AtbZIP60ΔC activated BiP promoters in a transient assay although full length did not, suggesting proteolysis triggers activation of the transcription activity. In a T-DNA tagged mutant of AtbZIP60, induction of one BiP gene was repressed. These results indicated that AtbZIP60 regulates the ER stress response in a manner specific to plants.
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© 2005 by The Japanese Society of Plant Physiologists
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