Abstract
Analysis of gene co-expression network can facilitate characterization and prediction of gene functions. We analyzed a mutual relationship between genes involved in amino acid biosynthesis using co-expression network constructed from publicly available correlation coefficient data of Arabidopsis (ATTED-II). The genes were clustered into three co-expressed groups. Group 1 contained the genes involved in valine, leucine, and isoleucine biosynthesis. Group 2 contained genes involved in arginine biosynthesis. Group 3 contained genes involved in glutamine, glutamate, serine, and glycine biosynthesis. We analyzed the co-expression patterns of the genes in each group with genes that were not directly involved in amino acid biosynthetic pathways. The result demonstrated the presence of the genes that could related the expression of amino acid biosynthesis genes. We are currently making overexpressors of these candidate genes in Arabidopsis T87 culture cells, and effects on the transcript and metabolite accumulation will be discussed.
