Abstract
DNA methylation at cytosine residues is an essential event required for the normal development of multicellular eukaryotes. In plant, a role for DNA methylation in pathogen resistance and genome integrity is well established, but the function of almost all DNA methylation in plant genomes remains unclear. Thus, identification of the degree and genome-wide distribution of DNA methylation would provide important clues to epigenetic machineries associated with development in plants and other organisms.
Recently, comprehensive maps of DNA methylation of the genome of Arabidopsis thaliana have been reported using whole-genome tiling arrays. Here we have generated DNA methylation profile (methylome) as well as sense transcription profiles (transcriptome), at 35-base pair resolution, of the genome derived from two accessions of A. thaliana. Some examples of genes which show different expression patterns with different DNA methylation between the two accessions will be shown.
