Abstract
Ubiquitin (Ub)/26S proteasome pathway plays an essential housekeeping role to eliminate the proteins which are damaged or misfolded. It is also essential for aspects of cellular regulation by removing short-lived regulatory proteins as a way to fine-tune homeostasis, adapt to new environments, and redirect growth and development. The 26S proteasome consists of two multisubunit complexes, 20S core particle (CP) and 19S regulatory particle (RP). The RP contains thirteen non-ATPase subunits (RPN) and a ring of six AAA-ATPase subunits (RPT).
We reported RPT2a deficient mutants and RPT5a deficient mutants resulted in enlarged leaves, which are caused by accelerated endoreduplication. On the other hand, RPT2b deficient mutants that are paralog of RPT2a didn't show such enlargement.
Here we report that one of the proteasome subunits likely plays a role in regulating expression of transgenes inserted in the genome. The relationship between the proteasome and this gene regulation will be discussed.
