Imaging features of congenital cytomegalovirus infection

Abstract

Congenital cytomegalovirus (CMV) infection is the most common type of TORCH syndrome, and it is estimated to occur at a frequency of 1 in 300 newborns. For symptomatic infants, the administration of valganciclovir within the first 2 months of life is effective. Treatment initiation should be considered for symptomatic infections, and abnormalities, such as intracranial calcifications or white matter lesions, which are observed on head imaging. The imaging findings vary depending on the timing of the infection, and some findings have been associated with the neurological prognosis and a risk of hearing loss. This article provides an overview of the clinical aspects of congenital CMV infection, including the imaging findings, and the differential diagnosis.