Abstract
The outcomes of patients with advanced cancer have improved with the advent of targeted molecular therapy．Yet，such therapies are associated with characteristic skin reactions，such as hand-foot syndrome，and the treatment of these skin lesions can be challenging．Here we report the case of an intractable and painful peristomal ulcer，suspected to have resulted from sunitinib use．A 53-year-old man underwent left nephrectomy for renal cell carcinoma and was subsequently administered sunitinib for multiple metastases．Perforation of rectal diverticulum was associated with peritonitis；sigmoid loop colostomy was performed．The patient developed an intractable and painful peristomal ulcer postoperatively．The skin lesion was confined to the circumference of the stoma（less than 2.5 cm from the margin），corresponding to the region covered by the fixing plate．The ulcer appeared to have developed from a minute wound caused by harness exchange that disturbed skin barrier function．
