2024 Volume 12 Issue 2 Pages 44-49
Recommended treatment for patients at high risk for recurrent preeclampsia is low-dose aspirin before 16 weeks’ gestation. Cases in which preeclampsia is suspected in the absence of hypertension, proteinuria, or organ damage, and cases of suspected preeclampsia before 20 weeks’ gestation are reported as atypical preeclampsia. We treated a patient with a history of early-onset preeclampsia in two previous pregnancies. Despite treatment with low-dose aspirin and low-molecular-weight heparin initiated in the first trimester, intrauterine fetal death occurred at 24 weeks’ gestation. Hypertension or proteinuria was not present, but the soluble Fms-like tyrosine kinase-1/placental growth factor ratio was high; considering her medical history, a diagnosis of atypical preeclampsia was rendered. Diagnosis and treatment at an early stage in patients at high risk for atypical preeclampsia must be considered. Additionally, for aspirin non-responders such as our patient, the establishment of treatments other than low-dose aspirin for effective preeclampsia prophylaxis is required.
