Prenatal risk assessment of gestational hypertension and preeclampsia using clinical information

Abstract

Aim: To assess the risks of developing gestational hypertension (GH) and preeclampsia (PE) during pregnancy based on clinical information.

Methods: Using the Perinatal Database of the Japan Society for Obstetrics and Gynecology between 2001 and 2010, we calculated logit scores of GH and PE by multivariate analysis to estimate their individual risk ratios.

Results: The logit score of PE was calculated with the equation -6.45797+0.0308815×(maternal age)-0.673456× (parity: 0 or 1)+0.13388×(fetal gender: boy 0 or girl 1)+1.95706×(pre-existing hypertension: 0 or 1)+1.16486× (pre-existing renal disease: 0 or 1)+0.0891015×(pre-pregnancy body mass index [BMI]). The estimated risk ratios predicted subsequent GH and PE with sensitivities of 61.5% and 67.0%, and specificities of 67.0% and 64.4%, respectively. The areas under the receiver operating characteristic curves for GH and PE were 0.70 and 0.68, respectively.

Conclusions: The estimated risk ratios determined in this study may identify women at high risk of GH or PE before disease onset.