NIHON SARUKOIDOSHISU / NIKUGESHUSHIKKAN (The Japanese journal of sarcoidosis and other granulomatous disorders )
Online ISSN : 1884-6122
Print ISSN : 1345-0565
ISSN-L : 1345-0565
Genes Related to the Induction of Interferon-γ in Sarcoidosis
Etsuro Yamaguchi
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2000 Volume 20 Issue 1 Pages 7-14

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Abstract
There is ample evidence for the involvement of IFN-γ in the formation of epithelioid cell granulomas, which are characteristic to sarcoid lesions. However, sarcoidosis does not belong to a typical Th1-type immune pathophysiology, in which only IFN-γ is working. It has a complex aspect in that IL-4 and other cytokines are involved depending on the stages and lesions of the disease. Upstream pathways have recently been elucidated which lead to the induction of IFN-γ. IL-12 and IL-18 are, among other things, play principal roles. Roles of IL-12 in sarcoidosis have already been documented, however, those of IL-18 have remained to be elucidated. Gene polymorphisms of IFN-γ, related cytokines, and signal transducing proteins may affect the occurrence and clinical course of sarcoidosis by modulating the production of IFN-γ.
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© Japan Society of Sarcoidosis and other Granulomatous Disorders
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