Abstract
We recently experienced two cases of sarcoidosis with hypercalcemia and progressive renal dysfunction. Case 1 was a 63 year old woman who complained of persistent proteinuria/haematuria and hypercalcemia. Renal biopsy revealed active interstitial nephritis with many epithelioid cell granulomas. Case 2 was a 60 year old woman who claimed for progressive renal dysfunction and hypercalcemia. Renal biopsy demonstrated a wide spread swelling and vacuoler degeneration among proximal tubular cells with little active interstitial nephritis. In both cases, renal function immediately improved by the oral administration of prednisolone (30mg/day). Thus, 2 different manners of tubuao-interstitial damages could induce progressive renal dysfunction in sarcoidosis patients. It was difficult to discriminate them by non-invasive examinations. Histological approach through renal biopsy seems essential for precise diagnosis and appropriate treatment.
