A Case of Sarcoidosis of in which Addition of Minocycline was Effective

Abstract

A woman with sarcoidosis showed progressive parenchymal shadows of the lung with worsening cough and sputum. Clarithromycin at a daily dose of 400mg for 3 months was not sufficiently effective for symptom relief. However, the chest shadows and her symptoms promptly disappeared following the addition of minocycline at a daily dose of 200mg. In view of other cases previously reported, the efficacy of minocycline is comparatively clear for sarcoidosis. The elucidation of the mechanism for this difference from the viewpoints of both antibacterial and immunomodulatory effects will create a stir in the controversies as to the etiology of sarcoidosis.