Abstract
Clinical investigation was made on the effect of adhesive materials used on ostomy appliances to be put on the peristomal skin.
Colostomates and ilesotomates were divided into the four groups：G-1：CMC synthetic rubber users,G-2：Acryl rubber-poly chloride users,G-3：Acryl rubber-paper users,G-4：Karaya users. And then,water volume in the stratum corneum and lipid on the skin surface were measured.
The structure of skin surface was discussed with silicon replica of the skins who have used either CMC,acryl or karaya for eight years.
Results：
Water volume in the stratum corneum was significantly lower at G-1,2,3 than control,but higher at G-4. Lipid on the skin surface was lower than control at all materials. All structures of the skin showed the same change.
