Abstract
Analysis of intra- or inter-cellular responses plays an important role in understanding the bio-functional mechanisms that are undergoing in a single cell or cell groups or tissue or organ, which led to advanced disease diagnosis and improved treatments. In nature, cells possess different functional activities and these activities control gene and protein expressions and cell function altogether. To understand the different functions of each cell, there is a need to develop microchip platforms, which can perform high-throughput screening and analysis of genes and proteins at individual cell level and single-molecule level. For achieving these goals, we developed in our laboratory different kinds of chip devices by employing micro and nano technology and applied these devices in single molecule DNA detection, in vitro protein synthesis and single-cell analysis. In this review, we mainly focus on the analysis of cellular signaling using cell chip device systems. This review has been divided mainly into three topics; high-throughput single-cell analysis system, drug screening system using neural cell chip and nanobiodevice for cell signaling detection.
