光を検出・利用した走査型顕微鏡 (SNOMなど) 走査型近接場光学顕微鏡による高分解能FISH法

山内 武志; 吉野 智之; 桑崎 誠剛; 末次 克行; 山本 公子; 大谷 敏郎; 杉山 滋

doi:10.1380/jsssj.28.536

Hyomen Kagaku

Online ISSN : 1881-4743
Print ISSN : 0388-5321
ISSN-L : 0388-5321

Advanced Analysis Notes

High-resolution FISH using Scanning Near-field Optical Microscopy

Takeshi YAMAUCHI, Tomoyuki YOSHINO, Seigo KUWAZAKI, Yoshitaka SUETSUGU, Kimiko YAMAMOTO, Toshio OHTANI, Shigeru SUGIYAMA

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Keywords: SPM, SNOM, biology, genomics, chromosome

JOURNAL FREE ACCESS

2007 Volume 28 Issue 9 Pages 536-538

DOI https://doi.org/10.1380/jsssj.28.536

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Abstract

We introduce fluorescence in situ hybridization technique using scanning near-field optical microscopy (SNOM) as an example of scanning probe microscopy (SPM) in biology. This enables us to find out specific nucleotide sequences on a chromosome with high-spatial resolution exceeding the diffraction-limit.

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この記事はクリエイティブ・コモンズ [表示 - 非営利 4.0 国際]ライセンスの下に提供されています。
https://creativecommons.org/licenses/by-nc/4.0/deed.ja

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