The registry of Japanese pancreas and islet transplantation 2019

Abstract

A total of 388 cases of pancreas transplantation from deceased, non-heart beating and living-related donors have been performed in 18 institutions in Japan as of the end of 2018 since April, 2000. The following donor- and recipient-related factors were analyzed: age and gender of donor and recipient, cause of death, histories of diabetes and dialysis, waiting period, total cold ischemic time, operative procedure, immunosuppression and survival rates of patient and graft. We showed the current status of pancreas transplantation in Japan. Although the donor conditions have improved every year, they were still mostly marginal. However, the outcome of pancreas transplants was considered to be comparable to that of the US and Europe. The patient survival is 96.3% and 94.9% at 1 and 5 years, respectively. Pancreas graft survival for SPK is 90.8% and 86.7% at 1 and 5 years, respectively. The most critical problem is that the pancreas graft survivals of PAK and PTA were significantly poorer than that of SPK. Another is that the early graft loss rate within 90 days after pancreas transplantation is 8.9%.

We should propose our original safety criteria for pancreas transplants to reduce the early graft loss and achieve a long-term graft survival.