Liver Machine Perfusion for the Storage, Assessment, and repair of Marginal Grafts

Abstract

The landscape of liver preservation has significantly changed during the past decade. The traditional cold static storage has been supplemented with novel strategies of cold and warm oxygenated perfusion as alterative or additional preservation techniques. While oxygenated liver perfusion was initially developed to reduce graft injury and increase the donor pool, the opportunity for graft assessment and repair during perfused graft preservation has triggered significant interest. The future of perfused liver preservation will likely be the combination of normothermic regional perfusion in the donor, followed by cold and warm oxygenated perfusion, depending on the donor type. Prolonged liver perfusion will offer exciting opportunities for graft modification in the years to come.