2023 Volume 58 Issue Supplement Pages s126_1
Background: Machine perfusion (MP) has not been widely used because of its low demand in Japan. Here, we report the first clinical trial of machine perfusion for kidney transplantation in Japan. We used the domestic machine to preserve the graft. The flow rate, perfusion pressure, renal resistance, and temperature were monitored during continuous hypothermic perfusion. Results: From August 2020 to the present, 15 cases of perfusion-preserved kidney transplantation have been performed. Of these, eleven and four cases were performed using organs donated after brain death (DBD) and cardiac death (DCD), respectively. The average age of the recipients was 54.5 years. The average total ischemic time was 693 minutes. The average MP time was 149.8 minutes. A total of 9 cases had delayed graft function. The best creatinine level during hospitalization was 1.30 mg/dL. There were no primary non-functional cases and perfusion preservation was safely performed in all cases. Conclusions: we present this report as the first clinical trial on machine perfusion for kidney transplantation from marginal donors with DBD and DCD in Japan
