Abstract
We described a patient with gender identity disorder (GID) and bipolar disorder treated with varenicline for smoking cessation. We followed the patient's wish to call her by last name. She discontinued smoking after 12 weeks from the administration of varenicline without adverse events; however, she resumed the habit of smoking several times. She maintained smoking cessation after noticing that interpersonal mental stress was the trigger of smoking, and we proposed some ways to cope with the mental stress. On smoking cessasion with varenicline for GID patients, not only attention to the exacerbation of psychiatric comorbidities and development of suicidal ideations but also an appreciation of gender diversity is important.
