Abstract
Objective: The aim of this study was to investigate quantity of environmental tobacco smoke (ETS) from husband and the risk of COPD in never smoking wife.
Methods: A study population aged over 40years and never smoking wife who have current or previous husband smoking enrolled in health checkup of COPD from May 2015 in Nagasaki Prefecture, Japan. They answered about the husband's smoking status and COPD questionnaire (IPAG) and performed spirometry. The index of ETS exposure from husband was calculated by number of cigarettes and years of smoking.
Results: Three hundred eight never smoking wives who exposed ETS (median: 432 [IQR: 210–800]) were included. Twenty (6.5%) subjects had IPAG > 16 point and FEV1/FVC < 70%. The ROC curve indicated a cut-off point of 735 for COPD risk (sensitivity: 0.80, specificity: 0.78, AUC: 0.85, p < 0.001). Furthermore, the cut-off point remained significantly associated with COPD risk after adjusted confounding factor (OR: 13.12,95%CI: 4.11–41.86).
Conclusion: This result suggests that the index accurately discriminated for COPD risk in never smoking wives exposed by ETS.
