Abstract
Background and Purpose:Abnormal secretion of adipocytokines from visceral fat tissue may be associated with the onset of stroke as well as development of atherosclerosis. The aim of this study was to examine the plasma adiponectin (ADPN) concentrations in each clinical subtype of stroke. Methods:From March 1, 2005 to February 28, 2006, 173 patients (111 men, 62 women; mean age, 71 years) with completed stroke who were admitted to our Stroke Care Unit within 7 days of the onset were enrolled. Fasting blood samples were obtained at 19 days on average after the onset of stroke. We measured the plasma ADPN concentrations with a sandwich ELISA system (adiponectin ELISA kit, Otsuka Pharmaceutical Co. Ltd.). Metabolic syndrome was diagnosed according to the criteria of the Japanese Society of Internal Medicine. Results:The ADPN concentrations were as follows:atherothrombotic brain infarction (ABI), 8.5±4.2; lacunar infarction (LI), 7.8±3.4; cardioembolic stroke (CES), 13.2±9.5; other types of infarction (OTI), 11.4±7.1; and intracerebral hemorrhage, 12.6±8.1 μg/ml. There was no significant difference in plasma ADPN concentration between brain infarction and hemorrhage. However, the plasma ADPN concentration in the thrombotic infarction group (ABI and LI) was significantly lower than that in the non-thrombotic infarction group (CES and OTI) (8.3±4.1 and 12.2±8.4 μg/ml, respectively;p=0.01).
Conclusion:Hypoadiponectinemia may be associated with thrombotic brain infarction
