Abstract
Background and Purpose: Anticoagulant-associated intracranial hemorrhage (ICH) typically presents with larger hematoma volumes, a higher risk of hematoma expansion, and worse outcomes than non anticoagulant-associated ICH. Administration of prothrombin complex concentrate (PCC) is indicated for urgent reversal of anticoagulation and is recommended by some guidelines in cases of warfarin-associated ICH.
Methods: We administered PCC to 18 patients who showed symptomatic ICH after receiving warfarin.
Results: The patients’ prothrombin time, international normalized ratio (PT-INR) normalized from 3.1±1.2 to 1.4±0.15 within 10 minutes of receiving PCC and was at 1.2±0.13 the morning after they received PCC. 15 patients had surgery, and their modified Rankin Scale (mRS) at the time of their discharge was stable or permissible extent, except for 1 patient who showed more severe symptoms at the visit.
Conclusions: In our series, coagulation time was quickly corrected by administration of PCC, and this could have contributed to a better outcome.
