Comparison of radical scavenging activity between original and generic edaravone drugs: absorption spectrophotometry study using 2,2-Diphenyl-1-picrylhydrazyl

Abstract

We compared radical scavenging activity using absorption spectrophotometry with 2,2-Diphenyl-1-picrylhydrazyl between the original (Radicut^®) and four generic edaravone drugs. The activity was significantly lower in three generic drugs than in the original drug (P<0.05). Whereas the original drug contains L-cysteine with radical scavenging activity, these three generic drugs do not. The difference of the additive may cause the radical scavenging activity among the original and generic edaravone drugs.