CKD and stroke

Abstract

Chronic kidney disease (CKD) is an independent risk factor for stroke, and it is reported that increase of albuminuria and reduction of estimated glomerular filtration rate (eGFR) cause higher risk of stroke. We examined a characteristic of the ischemic stroke patient with CKD. 62.8% patients had CKD, which defined as albumin-creatinine ratio (ACR) ≥30 mg/gCre or eGFR <60 ml/min/1.73m² or both. Cerebral white matter lesions and carotid artery IMT were advanced in the CKD groups compared with non-CKD group. The neurological severity at admission and discharge was worsened in ACR ≥30 mg/gCre groups. It is proposed that there are several mechanisms which correlate between CKD and stroke, such as risk factors for arteriosclerosis, endothelial dysfunction and similarity of vasculature. The stroke patient with CKD requires medical treatment that is careful to renal function, and is necessary to control a risk factor of arteriosclerosis and a risk factor peculiar to CKD.