A multicenter registry for acute stroke patients; Fukuoka Stroke Registry

Abstract

Fukuoka Stroke Registry (FSR) is a multicenter hospital-based registry. In this cohort, we are collecting the data from acute stroke patients. Kyushu University Hospital and six other stroke centers in Fukuoka participate in this registry. Using FSR data, we are doing risk-related, pathophysiological, and genomics- and proteomics-related studies. In this review, we introduce three recent topics of FSR. First topic is prestroke glycemic control and clinical outcomes of acute stroke patients. In this study, we have shown that poor glycemic control before stroke occurrence may be detrimental to clinical course after onset, and consequently lead to poor functional outcome of ischemic stroke. Second topic is Asian dust and stroke. In this study, we have shown that Asian dust may be specifically associated with the risk of atherothrombotic brain infarction. Last topic is research for biomarkers in ischemic stroke (REBIOS). In this study, we explored stroke-related proteins and investigated the precise functions of the proteins using in vitro and in vivo experiments. For example, we have shown that RANTES, a chemokine, is produced from neurons after ischemic stroke and may have a potential to protect neurons directly or indirectly through the production of neurotrophic factors in peri-infarct areas. Using FSR data and basic research, we are investigating the detailed pathphysiological mechanisms of cerebral ischemia.