Dabigatran related intracranial hemorrhage, five cases report

Abstract

We report five cases of intracranial hemorrhage related to dabigatran administration. All five cases bled after having changed medicine to dabigatran from Warfarin for non-valvular atrial fibrillation by a family doctor. The blood examination of five patients were almost normal values, and there were no history of previous subcutaneous bleeding or gastrointestinal bleeding. We performed a burr hole operation in one case without prior information of dabigatran administration, because of his stuporous state. Consequently, one patient died and the other went into a vegetative state. Only one patient displayed no significant disability after three months.