2021 Volume 43 Issue 5 Pages 462-466
The patient was a 56-year-old man who suffered from cerebral venous thrombosis 4 times. Peripheral blood and bone marrow aspirate smears at onset and during subsequent recurrence did not lead to a diagnosis of a myeloproliferative neoplasm. Later, platelets were elevated and anemia gradually worsened. Four years after onset, abnormal bone marrow findings were noted, and the patient was diagnosed with a myeloproliferative neoplasm associated with the JAK2 V617F mutation. In this case, cerebral venous thrombosis presumably recurred due to the myeloproliferative neoplasm associated with the JAK2 V617F mutation. There are a few reports of patients with the JAK2 V617F mutation who did not have abnormal blood test results when cerebral venous thrombosis developed but who were diagnosed with a myeloproliferative neoplasm several years later. In cases of unprovoked cerebral venous thrombosis, further testing must be performed with a latent myeloproliferative neoplasm associated with a JAK2 gene abnormality in mind.
