The clinical features of 40 patients with Trousseau syndrome at Toyota Kosei Hospital

Abstract

Background and Purpose: Cancer and stroke are the main causes of death in Japan. Some patients with cancer also have stroke. We retrospectively analyzed the clinical features of Trousseau syndrome. Methods: 40 patients with Trousseau syndrome of 2273 consecutive stroke patients except transient ischemic attack were admitted to our hospital between April 2009 and March 2016. We evaluated the origins, histological types, and stages of cancer related to Trousseau syndrome. Trousseau syndrome was defined as multiple cerebral infarctions with cancer-associated hypercoagulability. Results: The patients with Trousseau syndrome accounted for about 1.8% of a total of stroke patients. 27.5% of the patients with Trousseau syndrome were newly diagnosed as having occult cancer after stroke during medical treatment for acute phase. Lung cancer (11 cases) was the most common cancer. Adenocarcinoma (23 cases) was the most common histological type. Stage IV cancer (31 cases) was the most common cancer stage. Conclusions: It is important to search for occult cancer as soon as possible in terms of survival prognosis when we encounter multiple cerebral infarctions with hypercoagulability.