Abstract
The clinical significanse of the PVP-cAMP, cGMP levels in patients with cerebro-vascular disorder (CVD) of acute stage were investigated and such parameters were compared with the brain CT findings, the cAMP-, cGMP-PDE activities and β-TG levels in those patients. The PVP-cAMP, cGMP levels in patients with CVD of acute stage were higher than those of the healthy controls. The negative correlation was seen between Frithz's prognostic score and PVP-cGMP levels in patients with acute cerebral infarction and also this negative correlation was seen between Frithz's prognostic score and PVP-cAMP, cGMP levels in patients with acute cerebral bleeding. The positive correlation was seen between the enlargement of the low density area on brain CT findings and PVP-cGMP level in patients with acute cerebral infarction. Documentary, the negative correlation between PVP-cAMP, cGMP levels and cAMP-, cGMP-PDE activities and also the positive correlation between PVP-β-TG level and cAMP-, cGMP-PDE activities were evaluated at the onset of CVD. On the basis of these findings items, it is suggested that PVP-cAMP, cGMP levels in patients with CVD of acute stage were utilized for the sensitive indicator to prognosis and these cyclic nucleotides level fluctuation were mainly regulated by cAMP-, cGMP-PDE activities releasing from the platlet.
