Abstract
Computed tomography performed in conjunction with 39% stable xenon inhalation was used to evaluate regional differences in the autoregulation of cerebral blood flow (CBF). Ten monkeys (Macaca fuscata) of both sexes, weighing 5.5-9.0 kg, were used in the study. The local CBF was measured for 17 regions of interest (ROI) in the steady state and during hypotension induced by exsanguination. The 17 ROIs were divided into four groups. The steady-state CBF values in these groups were 90.8 ± 41.2 in the cerebral basal ganglia, 96.8 ± 35.1 in the cerebral cortex, 56.6 ± 21.1 in the cerebral white matter, and 50.0 ± 19.3 in the cerebellar hemisphere (ml/100 g brain/min, mean ± SD). Arterial blood gases and the hematocrit were determined concomitantly.
Cerebral autoregulation during hypotension induced by exsanguination was evaluated in terms of the mean autoregulation index [CBF mean (MABP 90-130 mmHg) -CBF50 (MABP50 mmHg) /CBF mean]. It was found that there was no statistically significant difference in the autoregulation of CBF among the cerebral basal ganglia, the cerebral cortex, the cerebral white matter and the cerebellar hemisphere.
