Abstract
At present available data concerning a relationship between cerebral hemodynamics and functional prognosis in cerebrovascular disease are meager and the results are inconsistent.
An attempt was made to correlate long-term functional prognosis with cerebral hemodynamics and oxygen consumption in patients with ischemic cerebrovascular disease.
In 46 patients with ischemic supratentorial cerebrovascular disease, cerebral blood flow (CBF) and cerebral metabolic rate of oxygen (CMRO2) were measured by the N2O method one to six months (mean, 62.7 days) after the onset of the disease. Two or more years after the measurement, the physical condition of the patients was evaluated by the questionnaire method. The patients were grouped according to functional status in walking, sphincter function, speech, and handling of chopsticks. Mean values for CBF and CMRO2 in patients with good functional recovery were, higher than those in patients with poor recovery. In particular, walking and sphincter function showed a significant relationship to either CBF or CMRO2. Multivariate analysis (quantification theory group I) of the data revealed that the value of CBF or CMRO2 was most closely related to the sphincter function of the patients.
The results suggest that CBF and CMRO2 values measured after acute stage are useful for estimating the long-term functional prognosis of patients with stroke.
