Abstract
Total cholesterol, triglyceride, HDL-cholesterol (by heparin-Mn2+ precipitation method) and lipoprotein fractionation (by cellulose acetate electrophoresis) were measured in 113 patients (83 men, 30 women) with TIA and cerebral infarction.
The diagnosis was determined by clinical course, clinical signs and neurological specific examinations of cerebrospinal fluid, computerized tomography and angiography.
The data of patients were compared with age-adjusted data in control groups of 110 men and 134 women.
Male patients with TIA and patients with cerebral infarction showed significantly lower HDL-cholesterol levels and all showed significantly lower a-lipoprotein (%) levels and significantly higher triglyceride, pre β- lipoprotein (%) and atherogenic index (TC-HDL.C/HDL.C) levels than those of the controls.
On the contrary, no differences were observed in total cholesterol and β-lipoprotein (%) levels of the patients with TIA and cerebral infarction.
HDL-cholesterol level was measured monthly after the attack for nine months in 16 cases with TIA and cerebral infarction. However, no significant changes in HDL-cholesterol levels were observed.
Thus, it might be considered that lower HDL-cholesterol and α-lipoprotein (%) levels are a negative risk factor of cerebral infarction.
