Abstract
The role of cell adhesion molecules and tissue factor as risk factor for brain infarction has been emphasized. By primate models of middle cerebral artery occlusion and reperfusion (MCA : O/R), we have tested the potential role of these molecules in the microvasculature in ischemic brain tissue. Significant increase of cell adhesion molecules (P-selectin, E-selectin, ICAM-1, and GP IIb/IIIa) of immunoreactive expression was recognized in the affected site of MCA : O/R. Infusion of monoclonal antibody of β 2 integrin subunit (CD 11 b), IB 4 produced significant increase in reflow. Preischemia infusion of the anti-tissue factor monoclonal anti-body, TF 9-6 B 4 resulted in significant reduction of intramicrovascular fibrin in MCA : O/R. These results in-dicate that cell adhesion molecules and tissue factor-mediated events may play an important role in the proc-esses of brain ischemia, coagulation system activation and inflammation, which are interrelated each other.
