Abstract
The aim of this prospective multicenter trial was to determine whether bypass surgery can prevent stroke recurrence in patients with major cerebral artery occlusive diseases and hemodynamic cerebral ischemia determined by quantitative measurement of cerebral blood flow, and whether improvement in hemodynamic cerebral ischemia by bypass surgery can prevent the progression of neuropsychological disorders or improve neuropsychological function. The subjects of this study were 206 patients who have been listed for 39 months from November 1st 1998 to March 31st 2002. Each patient underwent treatment according to the study program, and the 2-year follow-up survey of the patients is now underway. Of 206 patients listed in the study, 103 and 103 were assigned the medically-treated group and the surgically-treated group, respectively. Fifteen patients in the medically-treated group and six in the surgically-treated group reached primary endpoint. The incidence of stroke recurrence in the surgically-treated group was significantly lower than that in the medically-treated group (p=0.046). The final results will come out in March 2004.
