Abstract
We report the results of MELT Japan Study. This study was supported by Grants-in-Aid of the Ministry of Health, Welfare, and Labor, Japan. The patients with acute M1 or M2 occlusion within 6 hours from onset were included. They were randomized to the group that was treated using intra-arterial injection of urokinase (UK group) and to the group that was treated conservatively (Control group). The end point was defined the modified Rankin scale at three month. There are 115 registrations at October 2005. No difference is observed in the ratio of critical hemorrhagic transformation between two groups. The percentages of good outcome were 41.5% in UK group and 21.2% in Control group (p<0.034). MELT Japan has possibility to produce new knowledge in the treatment of the acute cerebral embolism though it progresses at present.
