1982 Volume 4 Issue 1 Pages 10-17
Using the canine thalamic infarction model, recirculation was allowed after two hours of occlusion. Changes in rCBF and EEG activity were determined at three locations in and around the infarctic focus, i.e., in the center of the focus, within its outer border and just outside the outer border.
Severe ischemia developed at the center of the focus due to vascular occlusion and there was attenuation of voltage and decreased fast wave components in the EEG. In the peripheral region of the infarction, there were no notable changes in the rCBF, but decreases in fast wave components and the appearance of slow waves was seen. In the region just external to the focus, there was slowly increasing hyperemia, but no changes in electrical activity of the brain were apparent.
Subsequent to recirculation, a long-lasting hyperemia arose at the center and periphery of the focus, and an abnormal CO2 response was found. The EEG showed gradual flattening of electrical activity. The hyperemia which appeared during occlusion at sites external to the focus recovered rapidly following recirculation, and no abnormalities in the CO2 response were seen in this region. Notable changes were not seen in the EEG.
