Abstract
A 39-year-old woman suddenly developed generalized convulsion after periodic administration of oral contraceptives (norgestrel 0.5 mg, ethinylestradiol 0.05 mg) for 5 months. CT scan showed small scattered intracerebral hemorrhage in the left frontal lobe and intravenous digital subtraction angiogram (IV-DSA) repeatedly demonstrated occlusion of the superior sagittal sinus at the anterior two third. Platelet aggregabilities were decreased on 9th day after onset. Intracranial pressure was well controlled by administration of mannitol and the patient was recovered without neurological deficits. Three months later, superior sagittal sinus was well recanalized at the anterior two third in the follow-up IV-DSA. Superior sagittal sinus thrombosis related to the oral contraceptives was still rare in Japan, and clinical features and hematological mechanism in relation to the thrombosis were discussed from the literature.
