1987 Volume 9 Issue 6 Pages 489-498
After the CT-era, tomographic measurment has been required for regional cerebral blood flow and metabolism. This paper descrives results on the quontitative studies of regional cerebral blood flow and oxygen metabolism in patients with cerebral stroke, studied using the 0-15 labelled gas steady-stete method and HEAD-TOME III by the PET-group of Akita. The results were summarized as follows.
1) Cerebral infarct with acute onset : 33 PET studies were carried out on the 16 subjects. Most of the lesions revealed considerable flow-metabolism mismatch : misery perfusion within the initial day, and then luxury perfusion up to 2 months. Threthold CBF causing tissue necrosis estimated at 17 ml/100 ml/min by PET.
2) Thrombosis of carotid artery with or without small infarct : Isodense tissues of the 31 patients were examined, Most of the subjects showed coupled decrease of flow/metabolism. Only 4 revealed critical reduction of flow and maintained metabolism with increased oxygen extraction. That would indicates that only a few of the patients could be indicated to EC/IC bypass surgery.
3) Hypertensive intracerbral hemorrhage : The 26 subjects were studied. A markedly ischemic zone was limitted just around a hematoma and luxury perfusion appeared only in 3 cases. Incresed intracranial pressure seemes to affect flow and metabolism of the patients with a hematoma lager than 4.5-5 cm in max, diameter. That should be considered for indication of surgical evacuation of a hematoma.
