Abstract
Measles virus, which derived from patients and was attenuated by intratesticular passages through guinea pigs, was inoculated into susceptible children by subcutaneous injection or intranasal spraying, Clininical and immunological findings observed were as follows:
1) A mild fever as well as change apparently the Koplik spot were found only in one case of ten, but neither katarrhal signs such as cough, sneeze or conjuctivitis nor eruptions were evident.
2) Of the blood picture, specific findings were: Initial leucocytosis followed by the leucopenia, relative neutropoilia and lymphopenia, as well as slight monocytosis and eoslnopenia. These changes were similar to those induces by the natural infection of meales.
3) It was deemed likely that the meales virus muliplied and the neutralizing antibodies were produced in the bodies of inoculated humans.
