1999 Volume 32 Issue 2 Pages 42-48
In order to investigate ECG changes during myocardial infarction and post-ischemic reperfusion, we need animal model that allows us to establish coronary occlusion with selected vessels, set occlusion time and manipulate the degree of myocardial injury and infarct size. In our study, we made Amplatz-type cardiac catheter for rabbits to develop non-invasive procedure. A stainless bead is attached at the tip of guide wire which was placed in the right or left coronary artery to produce occlusion and procedure for reperfusion was investigated. ECGs were recorded during occlusion and reperfusion of the left coronary artery, showing typical QT prolongation and elevation of ST segment and T wave, “Bead occlusion⁄reperfusion” is an effective procedure which can be used to study rabbit model of myocardial ischemia and infarction.
